We live in an age of paradox. A world more connected than ever, yet lonelier. Greater medical advances, yet rising lifestyle diseases. More information, yet a growing loss of meaning. The 21st century demands a new understanding of human flourishing. One that integrates cognitive ability, emotional depth, physical well-being, social behavior, and systems thinking. The MaNaS Roundtable in Boston is the first international convening that we have designed to respond boldly to this challenge. On October 6th, 2025, thought leaders and the brightest minds from neuroscience, psychology, integrative health, education, policy, and industry will come together to explore grand challenges in mental health and well-being, shape a shared vision for next-generation education, and identify strategic collaborations to drive systemic change. Hosted at MIT’s Samberg Center, this closed-door event is a step toward building a global network of collaborators that can co-create the future of mental health education, research, and practice.